What is the most effective procedure and medication for couples with unexplained infertility?

After fertility testing, we rarely see ‘unexplained infertility’. We used to think 15-20% of infertility was ‘unexplained’ (with regular cycles, open tubes, and good sperm) – with modern testing it’s under 1%. Ovarian reserve testing (ultrasound for ovarian volumes and antral follicle count, Antimullerian Hormone or AMH and the Clomid Challenge test) ‘explains’ a lot but there are other possible factors. See a board-certified Reproductive Endocrinology and Infertility or REI specialist for more detailed testing and to give you treatment choices: inseminations (IUI) combined with medications to increase the number of eggs IVF can be appropriate depending on your case.