Is IVF ever done without fertility drugs?

Yes, but natural cycle IVF (no fertility drugs) where only one egg is typically obtained or ‘minimal stimulation IVF’ with Clomid or low-dose fertility shots has much lower chances of success compared with ‘conventional IVF’ with higher doses of injectable medications when we are aiming to obtain multiple eggs. Costs are lower and the risk of multiple pregnancies is lower but the results are worse. More eggs give us a higher chance of having high-quality embryos from which to choose the best ones to transfer back into you.