They should have no major effects on sperm count. I’m assuming you’re talking about ‘regular’ prescription corticosteroids like triamcinolone (Kenalog) – these have little to no effect on sperm, unlike anabolic steroids like testosterone or Dianabol, which can cause major reductions in sperm count. Some studies indicate that heavy use of Non-Steroidal Anti-Inflammatory Drugs or NSAIDs, including aspirin, may affect sperm motility and sperm morphology (the % of normal-shaped sperm) as well.