What are the symptoms associated with primary ovarian insufficiency?

Irregular cycles or no periods, especially in a woman who was regular before, is a common sign. However there are many other causes of irregular cycles that we need to exclude, including Polycystic Ovarian Syndrome or PCOS. Hot flashes, vaginal dryness, or mood changes may occur, particularly if the woman’s periods are stopped. Some women with primary ovarian insufficiency still have regular periods but see a MD for difficulty getting pregnant.