Unfortunately, there is no treatment for severe male infertility that is 100% guaranteed to work using your own sperm. Donor sperm is the closest thing for couples where the male partner has azoospermia as it’s sperm from healthy men without known fertility issues. Having said that, many men with azoospermia can have children using their own surgically-retrieved epididymal or testicular sperm, combined with IVF with ICSI (In Vitro Fertilization with Intracytoplasmic Sperm Injection). A genetic test identifies some men ahead of time who won’t get sperm at retrieval. Having Donor sperm as a backup is a good idea.